In Dr Johnson’s opinion

Q: What are your thoughts regarding Quickclot?

Tuesday, December 8th, 2009

Q: What are your thoughts regarding Quickclot? One of the kids in my program recently had a fairly severe laceration to the knee and the bleeding was hard to control/messy. If the stuff works, it seems it may reduce possible contact with blood borne pathogens to staff.

“…the stuff works..”  or “…they make a difference…”, those are the suppositions that get to the heart of the matter.  I have written previously about clot enhancers and have expressed my unabashed skepticism.

In the last few years, the original QuikClot that was supposed to stop all bleeding without any harmful effects has been reformulated to be cooler because of concerns about burns.  Reengineered again, it is available, impregnated in gauze.  But do any of these really work?  There are anecdotal reports and animal studies.  The claims made by Z-Medica that their products have saved hundreds of lives seem hyperbolic and unsubstantiated by anything more than individual or pooled testimonials.  Each new animal trial shows the new product to be better than the prior one, the one that was supposed to stop all bleeding.( http://www.z-medica.com)  This is not science, this is marketing.  I am not aware of any clinical trials that look at important human outcome in any meaningful way.  The fact that someone, like the army, is using something does not make it efficacious or safe.  And in addition to burns, there have been other problems reported with the older formulations.  I don’t believe that the science with the other leading products (chitosan-based: e.g., http://www.celoxmedical.com) is any better.

I completely understand why the military wants a product that will stop bleeding easily.  Think about it.  As with all combat, bleeding is the major pathway to death.  Field treatment has improved significantly but who wouldn’t want to do better for otherwise healthy young women and men?  What could be better than being able to pour something into an exsanguinating wound and have the bleeding stop, especially where a tourniquet cannot be applied?  It does not work that way with any product on the market.  It does seem that the gauze formulations of each have some promise.  They can be wrapped around a wound or tightly stuffed into deeper ones and then secured by a tight pressure wrap.  Assuming that the product added is safe and effective, it could enhance what already works.

What should you do?  We know that bandaging that is visually directed toward the bleeding site (well-aimed), stuffed in for deeper wounds, and then secured by a pressure wrap have a good track record.  This is certainly true for the vast majority of wounds we are likely to see in non-combat, civilian events.  There are no confounding substances and anyone can buy these materials easily and inexpensively.  On the other hand, the least expensive of either of the major clot enhancing products retail for about 10$ US and many are 25$ US and more.  But wouldn’t it be worth it to decrease exposure to potential m thinking FG and OHbloodborne pathogens?  If there is bleeding, there is blood around.  Whether you use the sachet containing QuikClot or either gauze impregnated product, you still have to apply it manually and hold it in place like plain gauze until secured.  Gloves, eye protection, and clothing are still your best protection.  And what are you going to use if you haven’t got a clot enhancer with you?

Thoughts and Tips Regarding the Risk of H1N1

Wednesday, November 11th, 2009

girl with the fluIt is difficult to know how to respond to H1N1.  Last spring schools were closing with the first whiff of a possible infection.  Now, kids who are sick are segregated until they can be sent home.  Schools are unlikely to be closed unless the numbers of absentees are large enough to prevent normal function or vulnerable populations are put at risk.

Based on research, plain surgical masks were felt to afford insufficient protection compared to the more expensive, fitted, N95 mask.  This week, the result of an important N95 vs plain mask study is being questioned because of the methodology used.  Still, this is a big deal, especially for at risk populations like young kids, pregnant women and people over 65.  Underlying conditions like asthma and other chronic illnesses can increase a person’s risk for a more severe illness.

Influenza virus can be broadcast about 3 feet from droplets generated by coughing and sneezing.    The virus laden droplets gain access and infect through eye and nose mucous membranes.  This initial contact is either direct or indirect.  The later occurs when the droplets land on a surface and then are spread to the mucous membranes by hand contact.  It is often difficult to get more 3 feet away from someone in a tent, on-board ship or in a classroom.  Keeping surfaces clean under these kinds of circumstances can be a challenge.

Here is what I think:

  1. Most people with influenza are sick.  Cough, sore throat, headache or muscle aches with a fever should get your attention.
  2. Hand washing regularly both before but particularly after contact is very important.
  3. Coughing into a disposable tissue that is immediately thrown out or, lacking one, into one’s elbow crease will minimize spread potential.
  4. If you are running a program, isolating people with some symptoms will help.  In the middle of the ocean you cannot send the person home but you can use a mask and good hygiene.  If conditions permit, on deck, some distance from others would be better than being trapped below deck.   Think of this principle for other settings.
  5. Some kind of a mask is better than none and one mask for someone ill is cheaper and easier than one mask for everyone else.  It is hard to believe, if lacking a mask, that even a bandana wouldn’t offer at least some protection.
  6. Canceling or postponing a trip for the person with symptoms makes sense.
  7. When you think about hygiene don’t forget about things that you touch – e.g., flash lights, binoculars, GPS.  An outbreak of conjunctivitis at a college, reported in the NEJM in 2003, was felt to be related to ubiquitous public computer terminals.  Placing hand cleaner near them accompanied by instructions to use before and after was credited in part for getting things under control.
  8. Most of these steps make some sense to help minimize or contain many infectious illnesses.

The vast majority of people who contract H1N1 will survive just fine.  But, when you are not at home, little problems have a way of getting worse (magnifier effect), ultimately affecting everyone’s health and safety.  Expeditions or other remote missions are always easier and more fun when people are well.